William Harvey (April 1, 1578 – June 3, 1657) was an English medical doctor, who is credited with first correctly describing, in exact detail, the properties of blood being pumped around the body by the heart. This developed the ideas of René Descartes who in his Description of the Human Body said that the arteries and veins were pipes which carried nourishment around the body. Although Spanish physician Michael Servetus discovered circulation a quarter century before Harvey was born, all but three copies of his manuscript Christianismi Restitutio were destroyed and as a result, the secrets of circulation were lost until Harvey rediscovered them nearly a century later. Harvey travelled widely in the course of his researches, especially to Italy, where he stayed at the Venerable English College in Rome.
== Early life and education == Harvey was born in Folkestone, Kent, England(the nearest Hospital to Folkestone (in Ashford) is named after him) to a prosperous yeoman, and educated at The King's School, Canterbury, at Gonville and Caius College, Cambridge, from which he received a B.A. in 1597, and at the University of Padua (also attended by Copernicus), where he studied under [[Hieronymus Fabricius,and the Aristotelian philosopher Cesare Cremonini graduating in 1602. He returned to England and married Elizabeth Browne, daughter of Lancelot Browne, a prominent London physician. Havery never had children with Elizabeth. He became a doctor at St Bartholomew's Hospital in London (1609–43) and a Fellow of the Royal College of Physicians. After his time at St Bartholomew's he returned to Oxford and became Warden (head of house) of Merton College. In 1651 William Harvey donated money to the college for buliding and furnishing a library, which was dedicated in 1654. In 1656 he gave an endowment to pay a librarian and to present a yearly oration, which continues to happen in the present day in his honor. Harvey also left money in his will for the founding of a boys' school in his native town of Folkestone; opened in 1674, the Harvey Grammar School has had a continuous history to the present day.
New circulatory model
Many believe that both Servetus and Descartes merely re-discovered and extended early Muslim medicine especially the work of Ibn Nafis, who had laid out the principles and major arteries and veins in the 13th century.
Fabricius, Harvey's teacher at Padua, had claimed discovery of "valves" in veins, but had not discovered the true use of them. The explanation that he had put forward did not satisfy Harvey, and thus it became Harvey's endeavour to explain the true use of these valves, and eventually, the search suggested to him the larger question of the explanation of the motion of blood. Harvey announced his discovery of the circulatory system in 1616 and in 1628 published his work Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus (An Anatomical Exercise on the Motion of the Heart and Blood in Animals), where, based on scientific methodology, he argued for the idea that blood was pumped around the body by the heart before returning to the heart and being re-circulated in a closed system.
This clashed with the accepted model going back to Galen, who identified venous (dark red) and arterial (brighter and thinner) blood, each with distinct and separate functions. Venous blood was thought to originate in the liver and arterial blood in the heart; the blood flowed from those organs to all parts of the body where it was consumed. It was for exactly these reasons that the work of Ibn Nafis had been ignored.
Harvey based most of his conclusions on careful observations recorded during vivisections made of the human body during controlled experiments, being the first person to study biology quantitatively. Based on observations in endothermic animals, whose hearts beat slower and were thus easier to measure, Harvey realized the liver would have to produce 540 pounds of blood an hour, suggesting the blood was recycled and not constantly produced. He proposed that blood flowed through the heart in two separate closed loops. One loop, pulmonary circulation, connected circulatory system to the lungs. The second loop, systemic circulation, causes blood to flow to the vital organs and body tissue. He also observed that blood in veins would move readily towards the heart, but veins would not allow flow in the opposite direction. Harvey further concluded that the heart actually acted like a pump that forced blood to move throughout the body instead of the prevailing theory of his day that blood flow was caused by a sucking action of the heart and liver. These important theories of Harvey represent two significant contributions to the understanding the mechanisms of circulation.
Harvey also conducted research in embryology in his later career, writing On the Generation of Animals (De Generatione) in 1651. He supported the Aristotelian theory that embryos formed gradually and did not possess the characteristics of an adult in early stages. He also hypothesized the existence of a mammalian egg, and dissected dozens of deer in the King's hunting park in hopes of finding one, although he failed to do so.
Criticism of Harvey's work
Harvey's ideas were eventually accepted during his life-time. His work was attacked, notably by Jean Riolan in Opuscula anatomica (1649) which forced Harvey to defend himself in Exercitatio anatomica de circulatione sanguinis (also 1649) where he argued that Riolan's position was contrary to all observational evidence. Harvey was still regarded as an excellent doctor. He was personal physician to James I (1618-25). After his and others' attempts to cure James of his fatal illness failed, he became a scapegoat for that failure amidst rumours of a Catholic plot to kill James, but was saved by the personal protection of Charles I (to whom he was also personal physician, from 1625 to 1647). He took advantage of these royal position by dissecting deer from the royal parks and demonstrating the pumping of the heart on Viscount Montgomery's son, who had fallen from a horse when he was a boy, leaving a gap in his ribs, subsequently covered by a metal plate, which he was able to remove for Harvey. "I immediately saw a vast hole," Harvey wrote, and it was possible to feel and see the heart's beating through the scar tissue at the base of the hole.
His research notes were destroyed in riots in London at start of the English Civil War. He himself went with the king on campaign, and was in charge of the royal children's safety at the Battle of Edgehill, hiding them in a hedge with them reading a book, then forced by enemy fire to shelter behind the Royalist lines, and at the end of the battle tending to dying and wounded.
Harvey also became the Lumleian lecturer to the Royal College of Physicians (1615-56).
Marcello Malpighi later proved that Harvey's ideas on anatomical structure were correct; Harvey had been unable to distinguish the capillary network and so could only theorize on how the transfer of blood from artery to vein occurred.
Even so, Harvey's work had little effect on general medical practice at the time — blood letting, based on the prevailing Galenic tradition, was a popular practice, and continued to be so even after Harvey's ideas were accepted. Harvey's work did much to encourage others to investigate the questions raised by his research, and to revive the Muslim tradition of scientific medicine expressed by Nafis, Ibn Sina, and Rhazes. (See also: François Bernier)
Harvey was ranked #56 on Michael H. Hart's list of the most influential figures in history. Pulitzer Prize-winning historian Arthur Schlesinger Jr. also included him in his list of "The Ten Most Influential People of the Second Millennium" in the World Almanac & Book of Facts.
In his later years he suffered from gout and kidney stones, and tried to end his suffering by overdoesing on landanum. He is reported to have survived that attempt in 1652, only to die of a stroke in 1657, he was seventy-nine.
- 1628 Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus
- 1651 De Generatione
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